Ontology highlight
ABSTRACT:
SUBMITTER: Teschendorff AE
PROVIDER: S-EPMC4740178 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Teschendorff Andrew E AE Gao Yang Y Jones Allison A Ruebner Matthias M Beckmann Matthias W MW Wachter David L DL Fasching Peter A PA Widschwendter Martin M
Nature communications 20160129
Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding cancer aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast tissue samples, including 50 from cancer-free women and 84 from matched normal cancer pairs. We use statistical algorithms for dissecting intra- and inter-sample cellular heterogeneity and demonstrate that normal tissue adjacent to breast cancer is characterized by tens to thousands of epigenetic a ...[more]