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Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair.

ABSTRACT: The focus of this article is on the DNA binding and ATPase activities of the mismatch repair (MMR) protein, MutS-our current understanding of how this protein uses ATP to fuel its actions on DNA and initiate repair via interactions with MutL, the next protein in the pathway. Structure-function and kinetic studies have yielded detailed views of the MutS mechanism of action in MMR. How MutS and MutL work together after mismatch recognition to enable strand-specific nicking, which leads to strand excision and synthesis, is less clear and remains an active area of investigation.

SUBMITTER: Hingorani MM

PROVIDER: S-EPMC4740199 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair.

Hingorani Manju M MM

DNA repair 20151202

The focus of this article is on the DNA binding and ATPase activities of the mismatch repair (MMR) protein, MutS-our current understanding of how this protein uses ATP to fuel its actions on DNA and initiate repair via interactions with MutL, the next protein in the pathway. Structure-function and kinetic studies have yielded detailed views of the MutS mechanism of action in MMR. How MutS and MutL work together after mismatch recognition to enable strand-specific nicking, which leads to strand e ...[more]

PMID: 26704427

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