Ontology highlight
ABSTRACT:
SUBMITTER: Shamburek RD
PROVIDER: S-EPMC4740220 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Shamburek Robert D RD Bakker-Arkema Rebecca R Shamburek Alexandra M AM Freeman Lita A LA Amar Marcelo J MJ Auerbach Bruce B Krause Brian R BR Homan Reynold R Adelman Steve J SJ Collins Heidi L HL Sampson Maureen M Wolska Anna A Remaley Alan T AT
Circulation research 20151201 1
<h4>Rationale</h4>Low high-density lipoprotein-cholesterol (HDL-C) in patients with coronary heart disease (CHD) may be caused by rate-limiting amounts of lecithin:cholesterol acyltransferase (LCAT). Raising LCAT may be beneficial for CHD, as well as for familial LCAT deficiency, a rare disorder of low HDL-C.<h4>Objective</h4>To determine safety and tolerability of recombinant human LCAT infusion in subjects with stable CHD and low HDL-C and its effect on plasma lipoproteins.<h4>Methods and resu ...[more]