Ontology highlight
ABSTRACT:
SUBMITTER: Cao HM
PROVIDER: S-EPMC4740298 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
EBioMedicine 20150928 11
Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mim ...[more]