Ontology highlight
ABSTRACT:
SUBMITTER: Olfson E
PROVIDER: S-EPMC4740321 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Olfson E E Saccone N L NL Johnson E O EO Chen L-S LS Culverhouse R R Doheny K K Foltz S M SM Fox L L Gogarten S M SM Hartz S S Hetrick K K Laurie C C CC Marosy B B Amin N N Arnett D D Barr R G RG Bartz T M TM Bertelsen S S Borecki I B IB Brown M R MR Chasman D I DI van Duijn C M CM Feitosa M F MF Fox E R ER Franceschini N N Franco O H OH Grove M L ML Guo X X Hofman A A Kardia S L R SL Morrison A C AC Musani S K SK Psaty B M BM Rao D C DC Reiner A P AP Rice K K Ridker P M PM Rose L M LM Schick U M UM Schwander K K Uitterlinden A G AG Vojinovic D D Wang J-C JC Ware E B EB Wilson G G Yao J J Zhao W W Breslau N N Hatsukami D D Stitzel J A JA Rice J J Goate A A Bierut L J LJ
Molecular psychiatry 20150804 5
The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences nicotine dependence risk, we performed targeted sequencing on 1582 nicotine-dependent cases (Fagerström Test for Nicotine Dependence score⩾4) and 1238 non-dependent controls, with independent replicat ...[more]