Ontology highlight
ABSTRACT:
SUBMITTER: Bulla R
PROVIDER: S-EPMC4740357 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160201
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. Compared with wild-type (WT) or C3- or C5-deficient mice, C1q-deficient (C1qa(-/-)) mice bearing a syngeneic B16 melanoma exhibit a slower tumour growth and prolonged survival. This effect is not attributable to differences ...[more]