Impaired intracellular trafficking defines early Parkinson's disease.
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ABSTRACT:
SUBMITTER: Hunn BH
PROVIDER: S-EPMC4740565 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Impaired intracellular trafficking defines early Parkinson's disease.
Hunn Benjamin H M BH Cragg Stephanie J SJ Bolam J Paul JP Spillantini Maria-Grazia MG Wade-Martins Richard R
Trends in neurosciences 20150129 3
Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and represents a significant cost to individuals, carers, and ageing societies. It is defined at post-mortem by the loss of dopamine neurons in the substantia nigra together with the presence of Lewy bodies and Lewy neurites. We examine here the role of α-synuclein and other cellular transport proteins implicated in PD and how their aberrant activity may be compounded by the unique anatomy of the dopaminergic neuro ...[more]
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