Ontology highlight
ABSTRACT:
SUBMITTER: Richards EJ
PROVIDER: S-EPMC4741487 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Richards Edward J EJ Permuth-Wey Jennifer J Li Yajuan Y Chen Y Ann YA Coppola Domenico D Reid Brett M BM Lin Hui-Yi HY Teer Jamie K JK Berchuck Andrew A Birrer Michael J MJ Lawrenson Kate K Monteiro Alvaro N A AN Schildkraut Joellen M JM Goode Ellen L EL Gayther Simon A SA Sellers Thomas A TA Cheng Jin Q JQ
Oncotarget 20151001 33
The homeobox A (HOXA) region of protein-coding genes impacts female reproductive system embryogenesis and ovarian carcinogenesis. The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplored in epithelial ovarian cancer (EOC). We evaluated whether common genetic variants in these lncRNAs are associated with EOC risk and/or have functional roles in EOC development. Using genome-wide association study data from 1,201 serous EOC cas ...[more]