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MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7.


ABSTRACT: Whereas miR-101 is involved in the development and progression of breast cancer, the underlying molecular mechanisms remain to be elucidated. Here, we report that miR-101 expression is inversely correlated with the clinical stage, lymph node metastasis and prognosis in breast cancers. Introduction of miR-101 inhibited breast cancer cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis of in vivo. CX chemokine receptor 7 (CXCR7) is a direct target of miR-101, positively correlating with the histological grade and the incidence of lymph node metastasis in breast cancer patients. The effects of miR-101 were mimicked and counteracted by CXCR7 depletion and overexpression, respectively. STAT3 signaling downstream of CXCR7 is involved in miR-101 regulation of breast cancer cell behaviors. These findings have implications for the potential application of miR-101 in breast cancer treatment.

SUBMITTER: Li JT 

PROVIDER: S-EPMC4741570 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7.

Li Jun-Tang JT   Jia Lin-Tao LT   Liu Ning-Ning NN   Zhu Xiao-Shan XS   Liu Qin-Qin QQ   Wang Xiu-Li XL   Yu Feng F   Liu Yan-Li YL   Yang An-Gang AG   Gao Chun-Fang CF  

Oncotarget 20151001 31


Whereas miR-101 is involved in the development and progression of breast cancer, the underlying molecular mechanisms remain to be elucidated. Here, we report that miR-101 expression is inversely correlated with the clinical stage, lymph node metastasis and prognosis in breast cancers. Introduction of miR-101 inhibited breast cancer cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis of in vivo. CX chemokine receptor 7 (CXCR7) is a direct target of miR-101, po  ...[more]

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