Targeting FER Kinase Inhibits Melanoma Growth and Metastasis.
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ABSTRACT:
SUBMITTER: Ivanova IA
PROVIDER: S-EPMC6468679 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Publications
Targeting FER Kinase Inhibits Melanoma Growth and Metastasis.
Ivanova Iordanka A IA Arulanantham Shinthujah S Barr Kevin K Cepeda Mario M Parkins Katie M KM Hamilton Amanda M AM Johnston Danielle D Penuela Silvia S Hess David A DA Ronald John A JA Dagnino Lina L
Cancers 20190324 3
Melanoma is one of the most aggressive types of tumors and exhibits high metastatic potential. Fes-related (FER) kinase is a non-receptor tyrosine kinase that has been implicated in growth and metastasis of various epithelial tumors. In this study, we have examined the role that FER kinase plays in melanoma at the molecular level. FER-depleted melanoma cells exhibit impaired Wnt/β-catenin pathway activity, as well as multiple proteomic changes, which include decreased abundance of L1-cell adhesi ...[more]
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