Ontology highlight
ABSTRACT:
SUBMITTER: Setti M
PROVIDER: S-EPMC4741615 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Setti Matteo M Osti Daniela D Richichi Cristina C Ortensi Barbara B Del Bene Massimiliano M Fornasari Lorenzo L Beznoussenko Galina G Mironov Alexandre A Rappa Germana G Cuomo Alessandro A Faretta Mario M Bonaldi Tiziana T Lorico Aurelio A Pelicci Giuliana G
Oncotarget 20151001 31
Little progresses have been made in the treatment of glioblastoma (GBM), the most aggressive and lethal among brain tumors. Recently we have demonstrated that Chloride Intracellular Channel-1 (CLIC1) is overexpressed in GBM compared to normal tissues, with highest expression in patients with poor prognosis. Moreover, CLIC1-silencing in cancer stem cells (CSCs) isolated from human GBM patients negatively influences proliferative capacity and self-renewal properties in vitro and impairs the in viv ...[more]