Ontology highlight
ABSTRACT:
SUBMITTER: Henry C
PROVIDER: S-EPMC4741897 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Henry Claire C Llamosas Estelle E Knipprath-Meszaros Alexandra A Schoetzau Andreas A Obermann Ellen E Fuenfschilling Maya M Caduff Rosemarie R Fink Daniel D Hacker Neville N Ward Robyn R Heinzelmann-Schwarz Viola V Ford Caroline C
Oncotarget 20151101 37
<h4>Aim</h4>In recent years, the Wnt signalling pathway has been implicated in epithelial ovarian cancer and its members have potential as diagnostic, prognostic and therapeutic targets. Here we investigated the role of two Wnt receptor tyrosine kinases (RTKs), ROR1 and ROR2, and their putative ligand, Wnt5a, in ovarian cancer.<h4>Methods</h4>Immunohistochemistry for ROR2 was performed in a large patient cohort, including benign controls, borderline tumours and epithelial ovarian cancer. In addi ...[more]