Ontology highlight
ABSTRACT:
SUBMITTER: Liu PL
PROVIDER: S-EPMC5519074 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Liu Po-Len PL Liu Wei-Lun WL Chang Jia-Ming JM Chen Yung-Hsiang YH Liu Yu-Peng YP Kuo Hsuan-Fu HF Hsieh Chong-Chao CC Ding Yu-Sian YS Chen Wei-Wei WW Chong Inn-Wen IW
PloS one 20170720 7
MicroRNAs (miRs) play critical roles in cancer development, proliferation, epithelial-mesenchymal transition (EMT), invasion, and migration through regulating the expression of oncogenes and tumour suppressor genes. Previous studies have indicated that miR-200c acts as a tumour suppressor in various cancers by downregulating high-mobility group box 1 (HMGB1) and thereby suppressing EMT and metastasis. In addition, miR-200c was reported to be downregulated and correlated with poor outcomes in non ...[more]