Ontology highlight
ABSTRACT:
SUBMITTER: Minas TZ
PROVIDER: S-EPMC4741957 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Minas Tsion Zewdu TZ Han Jenny J Javaheri Tahereh T Hong Sung-Hyeok SH Schlederer Michaela M Saygideğer-Kont Yasemin Y Çelik Haydar H Mueller Kristina M KM Temel Idil I Özdemirli Metin M Kovar Heinrich H Erkizan Hayriye Verda HV Toretsky Jeffrey J Kenner Lukas L Moriggl Richard R Üren Aykut A
Oncotarget 20151101 35
Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS family fusion proteins and over-expressed ETS proteins are also found in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients. Transgenic expression of EWS-FLI1 in mice promotes high penetrance erythroid leukemia with ...[more]