Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC5706912 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Sun Wenjing W Rojas Yesenia Y Wang Hao H Yu Yang Y Wang Yongfeng Y Chen Zhenghu Z Rajapakshe Kimal K Xu Xin X Huang Wei W Agarwal Saurabh S Patel Roma H RH Woodfield Sarah S Zhao Yanling Y Jin Jingling J Zhang Hong H Major Angela A Hicks M John MJ Shohet Jason M JM Vasudevan Sanjeev A SA Coarfa Cristian C Yang Jianhua J Nuchtern Jed G JG
Oncotarget 20171019 55
Treatment failure in high risk neuroblastoma (NB) is largely due to the development of chemotherapy resistance. We analyzed the gene expression changes associated with exposure to chemotherapy in six high risk NB tumors with the aid of the Connectivity Map bioinformatics platform. Ten therapeutic agents were predicted to have a high probability of reversing the transcriptome changes associated with neoadjuvant chemotherapy treatment. Among these agents, initial screening showed the EWS-FLI1 and ...[more]