Ontology highlight
ABSTRACT:
SUBMITTER: Chang JS
PROVIDER: S-EPMC4742177 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Chang Jeng-Shou JS Su Chia-Yi CY Yu Wen-Hsuan WH Lee Wei-Jiunn WJ Liu Yu-Peng YP Lai Tsung-Ching TC Jan Yi-Hua YH Yang Yi-Fang YF Shen Chia-Ning CN Shew Jin-Yuh JY Lu Jean J Yang Chih-Jen CJ Huang Ming-Shyan MS Lu Pei-Jung PJ Lin Yuan-Feng YF Kuo Min-Liang ML Hua Kuo-Tai KT Hsiao Michael M
Oncotarget 20151101 34
G-protein-coupled receptor kinase interacting protein 1 (GIT1) is participated in cell movement activation, which is a fundamental process during tissue development and cancer progression. GIT1/PIX forming a functional protein complex that contributes to Rac1/Cdc42 activation, resulting in increasing cell mobility. Although the importance of Rac1/Cdc42 activation is well documented in cancer aggressiveness, the clinical importance of GIT1 remains largely unknown. Here, we investigated the clinic ...[more]