Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC4742188 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ding Ling L Liang Guikai G Yao Zhangting Z Zhang Jieqiong J Liu Ruiyang R Chen Huihui H Zhou Yulu Y Wu Honghai H Yang Bo B He Qiaojun Q
Oncotarget 20151101 34
Accumulated evidence suggests that M2-like polarized tumor associated macrophages (TAMs) plays an important role in cancer progression and metastasis, establishing TAMs, especially M2-like TAMs as an appealing target for therapy intervention. Here we found that metformin significantly suppressed IL-13 induced M2-like polarization of macrophages, as illustrated by reduced expression of CD206, down-regulation of M2 marker mRNAs, and inhibition of M2-like macrophages promoted migration of cancer ce ...[more]