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Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.


ABSTRACT: Dietary restriction has been recognized as a healthy and natural therapy for cancer. It is reported that different forms of dietary restriction can promote anti-tumor immunity. However, it is not clear how fasting affects tumor-associated macrophages (TAMs). This study aims to investigate the relationship between fasting and antitumor immunity in terms of tumor-associated macrophages. In vivo, the results showed that alternate day fasting for 2 weeks inhibitted the tumor growth of mice without causing a reduction of body weight. Meanwhile, M2 polarization of tumor-associated macrophages in tumor tissues of alternate day fasting group was also decreased. In vitro, fasting induced the autophagy of CT26 cells, decreased the generation of extracellular adenosine by supressing the expression of CD73 in CT26 cells. Decreasing adenosine inhibitted M2 polarization of RAW264.7 cells through inactivating JAK1/STAT3 signal pathway in fasting condition. Eventually, the proliferation of CT26 cancer cells declined on account of fasting-facilitated antitumor immunity. These results suggested that fasting suppressed M2 polarization of tumor-associated macrophages to inhibit tumor growth through decreasing the level of adenosine in the tumor microenvironment both in vivo and in vitro. This process was associated with increasing autophagy of tumor cells.

SUBMITTER: Sun P 

PROVIDER: S-EPMC5650369 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages.

Sun Pengfei P   Wang Huihui H   He Zhiyong Z   Chen Xiangyuan X   Wu Qichao Q   Chen Wankun W   Sun Zhirong Z   Weng Meilin M   Zhu Minmin M   Ma Duan D   Miao Changhong C  

Oncotarget 20170816 43


Dietary restriction has been recognized as a healthy and natural therapy for cancer. It is reported that different forms of dietary restriction can promote anti-tumor immunity. However, it is not clear how fasting affects tumor-associated macrophages (TAMs). This study aims to investigate the relationship between fasting and antitumor immunity in terms of tumor-associated macrophages. <i>In vivo,</i> the results showed that alternate day fasting for 2 weeks inhibitted the tumor growth of mice wi  ...[more]

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