Ontology highlight
ABSTRACT:
SUBMITTER: Nagle SJ
PROVIDER: S-EPMC4742356 | biostudies-literature | 2016 Jan-Feb
REPOSITORIES: biostudies-literature
Nagle Sarah J SJ Garfall Alfred L AL Stadtmauer Edward A EA
Cancer journal (Sudbury, Mass.) 20160101 1
Relapsed and refractory hematologic malignancies have a very poor prognosis. Chimeric antigen receptor T cells are emerging as a powerful therapy in this setting. Early clinical trials of genetically modified T cells for the treatment of non-Hodgkin lymphoma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia have shown high complete response rates in patients with few therapeutic options. Exploration is ongoing for other hematologic malignancies including multiple myeloma, acute mye ...[more]