Ontology highlight
ABSTRACT:
SUBMITTER: Rotolo A
PROVIDER: S-EPMC6814196 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Rotolo Antonia A Karadimitris Anastasios A Ruella Marco M
Leukemia & lymphoma 20171122 9
Chimeric antigen receptor T cell (CART) therapy has dramatically changed the therapeutic prospects for B cell malignancies. Over the last decade CD19-redirected CART have demonstrated the ability to induce deep, long-lasting remissions and possibly cure patients with relapsing B cell neoplasms. Such impressive results with CART19 fostered efforts to expand this technology to other incurable malignancies that naturally do not express CD19, such as acute myeloid leukemia (AML), Hodgkin lymphoma (H ...[more]