Ontology highlight
ABSTRACT:
SUBMITTER: Song P
PROVIDER: S-EPMC4742389 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Song Pingping P Li Shanshan S Wu Hao H Gao Ruize R Rao Guanhua G Wang Dongmei D Chen Ziheng Z Ma Biao B Wang Hongxia H Sui Nan N Deng Haiteng H Zhang Zhuohua Z Tang Tieshan T Tan Zheng Z Han Zehan Z Lu Tieyuan T Zhu Yushan Y Chen Quan Q
Protein & cell 20160108 2
Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson's disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, the underlying molecular mechanism linking parkin with the etiology of PD remains elusive. Here we report that p62, a critical regulator for protein quality control, inclusion body formation, selective autophagy and diverse ...[more]