Ontology highlight
ABSTRACT:
SUBMITTER: Macaulay IC
PROVIDER: S-EPMC4742565 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Macaulay Iain C IC Svensson Valentine V Labalette Charlotte C Ferreira Lauren L Hamey Fiona F Voet Thierry T Teichmann Sarah A SA Cvejic Ana A
Cell reports 20160121 4
The transcriptional programs that govern hematopoiesis have been investigated primarily by population-level analysis of hematopoietic stem and progenitor cells, which cannot reveal the continuous nature of the differentiation process. Here we applied single-cell RNA-sequencing to a population of hematopoietic cells in zebrafish as they undergo thrombocyte lineage commitment. By reconstructing their developmental chronology computationally, we were able to place each cell along a continuum from s ...[more]