Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers.
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ABSTRACT: Background
Luminal A breast cancer defined as hormone receptor positive and human epidermal growth factor receptor 2 (HER2) negative is known to be heterogeneous. Previous study showed that luminal A tumours with the expression of basal markers ((cytokeratin (CK) 5 or CK5/6) or epidermal growth factor receptor (EGFR)) were associated with poorer prognosis compared with those that stained negative for basal markers. Prompted by this study, we assessed whether tumour characteristics and risk factors differed by basal marker status within luminal A tumours.Methods
We pooled 5040 luminal A cases defined by immunohistochemistry (4490 basal-negative ((CK5 (or CK5/6))- and EGFR-) and 550 basal-positive ((CK5 (or CK5/6+)) or EGFR+)) from eight studies participating in the Breast Cancer Association Consortium. Case-case comparison was performed using unconditional logistic regression.Results
Tumour characteristics and risk factors did not vary significantly by the expression of basal markers, although results suggested that basal-positive luminal tumours tended to be smaller and node negative, and were more common in women with a positive family history and lower body mass index.Conclusions
Most established breast cancer risk factors were similar in basal-positive and basal-negative luminal A tumours. The non-significant but suggestive differences in tumour features and family history warrant further investigations.
SUBMITTER: Sung H
PROVIDER: S-EPMC4742579 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers.
Sung Hyuna H Garcia-Closas Montserrat M Chang-Claude Jenny J Blows Fiona M FM Ali H Raza HR Figueroa Jonine J Nevanlinna Heli H Fagerholm Rainer R Heikkilä Päivi P Blomqvist Carl C Giles Graham G GG Milne Roger L RL Southey Melissa C MC McLean Catriona C Mannermaa Arto A Kosma Veli-Matti VM Kataja Vesa V Sironen Reijo R Couch Fergus J FJ Olson Janet E JE Hallberg Emily E Olswold Curtis C Cox Angela A Cross Simon S SS Kraft Peter P Tamimi Rulla M RM Eliassen A Heather AH Schmidt Marjanka K MK Bolla Manjeet K MK Wang Qin Q Easton Douglas D Howat William J WJ Coulson Penny P Pharoah Paul D P PD Sherman Mark E ME Yang Xiaohong R XR
British journal of cancer 20151217 3
<h4>Background</h4>Luminal A breast cancer defined as hormone receptor positive and human epidermal growth factor receptor 2 (HER2) negative is known to be heterogeneous. Previous study showed that luminal A tumours with the expression of basal markers ((cytokeratin (CK) 5 or CK5/6) or epidermal growth factor receptor (EGFR)) were associated with poorer prognosis compared with those that stained negative for basal markers. Prompted by this study, we assessed whether tumour characteristics and ri ...[more]
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