Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.

ABSTRACT:

Background

Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding.

Methods

Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days.

Results

Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (Pinteraction=0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adeno

SUBMITTER: Elshorbagy AK 

PROVIDER: S-EPMC4742722 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature