Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNAs in Peripheral Blood Cell in Nonallergic Childhood Asthma

ABSTRACT: We aimed to apply microRNA to explore the underlying mechanism of nonallergic childhood asthma

ORGANISM(S): Homo sapiens

PROVIDER: GSE222775 | GEO | 2023/04/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

MicroRNAs in Peripheral Blood Cell in Nonallergic Childhood Asthma

Project description:MicroRNAs in Peripheral Blood Cell in Nonallergic Childhood Asthma

| PRJNA923352 | ENA

Childhood Atopic Asthma

Project description:Childhood Atopic Asthma

| PRJNA273399 | ENA

Circulating microRNAs: Association with lung function in asthma

2016-06-09 | GSE74770 | GEO

Circulating microRNAs: Association with lung function in asthma

Project description:Blood serum from 160 Childhood Asthma Management Program (CAMP) subjects were microRNA profiles with 13 subjects profiled twice. Each subject has diverse clinical phenotypes notably spirometry related phenotypes. Least squares linear regression was applied with subject phenotypes as the dependent variable, and microRNA Ct values (data matrix quantile normalized) as the independent variable to identify significant associations between subject phenotype and microRNA abundance.

2016-06-09 | E-GEOD-74770 | biostudies-arrayexpress

Circulating MicroRNAs and Treatment Response in Childhood Asthma

Project description:Circulating MicroRNAs and Treatment Response in Childhood Asthma

| PRJNA556710 | ENA

Gene expression profiling of peripheral blood from uncontrolled and controlled asthma

Project description:We analyzed the transcriptomes of children with controlled and uncontrolled asthma in Taiwanese Consortium of Childhood Asthma Study (TCCAS). Hierarchical clustering, differentially expressed gene (DEG), weighted gene co-expression network analysis (WGCNA) and pathway enrichment methods were performed, to investigate important genes between two groups.

2021-11-09 | GSE188424 | GEO

Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma

Project description:Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication studies the 17q21 locus showed strong association with diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (P = 0.0003) and in 3,301 subjects from the British 1958 Birth Cohort (P = 0.0005). We systematically evaluated the relationships between markers of the 17q21 locus and transcript levels of genes in EBV-transformed lymphoblastoid cell lines from children in the asthma family panel used in our association study. The SNPs associated with childhood asthma were consistently and strongly associated (P <10-22) in cis with transcript levels of ORMDL3, a member of a gene family that encode transmembrane proteins anchored in the endoplasmic reticulum. The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. Experiment Overall Design: Gene expression levels were evaluated in 404 children. We then evaluated the relationship between SNPs in the 17q21 region (which show association to asthma in the same children) with gene expression levels. See http://www.sph.umich.edu/csg/liang/asthma/

2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress

Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma

Project description:Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication studies the 17q21 locus showed strong association with diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (P = 0.0003) and in 3,301 subjects from the British 1958 Birth Cohort (P = 0.0005). We systematically evaluated the relationships between markers of the 17q21 locus and transcript levels of genes in EBV-transformed lymphoblastoid cell lines from children in the asthma family panel used in our association study. The SNPs associated with childhood asthma were consistently and strongly associated (P <10-22) in cis with transcript levels of ORMDL3, a member of a gene family that encode transmembrane proteins anchored in the endoplasmic reticulum. The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. Keywords: association study, global gene expression, asthma, ORMDL3

2007-07-01 | GSE8052 | GEO

Gene expression profiling of whole blood and peripheral neutrophils from asthma.

Project description:As part of the Taiwanese Consortium of Childhood Asthma Study (TCCAS), a new prospective sub-study was conducted to investigate the effectiveness of inhaled corticosteroids (ICS) treatment. Patients were categorized as either responders (R) or non-responders (NR), based on the improvement of their pulmonary function after ICS treatment. We analyzed the transcriptomes of asthma with ICS non-responsers and responders.

2023-04-24 | GSE230048 | GEO

Nasal DNA methylation is associated with childhood asthma

Project description:Nasal DNA methylation is associated with childhood asthma

| PRJNA430896 | ENA