Ontology highlight
ABSTRACT:
SUBMITTER: Wu G
PROVIDER: S-EPMC4267695 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Wu Gongxiong G Hu Weiguo W Shahsafaei Aliakbar A Song Wenping W Dobarro Martin M Sukhova Galina K GK Bronson Rod R RR Shi Guo-Ping GP Rother Russell P RP Halperin Jose A JA Qin Xuebin X
Circulation research 20090108 4
Complement is a central effector system within the immune system and is implicated in a range of inflammatory disorders. CD59 is a key regulator of complement membrane attack complex (MAC) assembly. The atherogenic role of terminal complement has long been suspected but is still unclear. Here, we demonstrate that among mice deficient in apolipoprotein (Apo)E, the additional loss of murine CD59 (mCd59ab(-/-)/ApoE(-/-)) accelerated advanced atherosclerosis featuring occlusive coronary atherosclero ...[more]