Ontology highlight
ABSTRACT:
SUBMITTER: Russo M
PROVIDER: S-EPMC4744519 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Russo Mariangela M Siravegna Giulia G Blaszkowsky Lawrence S LS Corti Giorgio G Crisafulli Giovanni G Ahronian Leanne G LG Mussolin Benedetta B Kwak Eunice L EL Buscarino Michela M Lazzari Luca L Valtorta Emanuele E Truini Mauro M Jessop Nicholas A NA Robinson Hayley E HE Hong Theodore S TS Mino-Kenudson Mari M Di Nicolantonio Federica F Thabet Ashraf A Sartore-Bianchi Andrea A Siena Salvatore S Iafrate A John AJ Bardelli Alberto A Corcoran Ryan B RB
Cancer discovery 20151207 2
<h4>Unlabelled</h4>How genomic heterogeneity associated with acquired resistance to targeted agents affects response to subsequent therapy is unknown. We studied EGFR blockade in colorectal cancer to assess whether tissue and liquid biopsies can be integrated with radiologic imaging to monitor the impact of individual oncogenic alterations on lesion-specific responses. Biopsy of a patient's progressing liver metastasis following prolonged response to cetuximab revealed a MEK1(K57T) mutation as a ...[more]