Ontology highlight
ABSTRACT:
SUBMITTER: Saxon JA
PROVIDER: S-EPMC4744539 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Saxon Jamie A JA Cheng Dong-Sheng DS Han Wei W Polosukhin Vasiliy V VV McLoed Allyson G AG Richmond Bradley W BW Gleaves Linda A LA Tanjore Harikrishna H Sherrill Taylor P TP Barham Whitney W Yull Fiona E FE Blackwell Timothy S TS
Journal of immunology (Baltimore, Md. : 1950) 20160115 4
Although numerous studies have demonstrated a critical role for canonical NF-κB signaling in inflammation and disease, the function of the noncanonical NF-κB pathway remains ill-defined. In lung tissue from patients with acute respiratory distress syndrome, we identified increased expression of the noncanonical pathway component p100/p52. To investigate the effects of p52 expression in vivo, we generated a novel transgenic mouse model with inducible expression of p52 in Clara cell secretory prot ...[more]