Ontology highlight
ABSTRACT:
SUBMITTER: Yang CJ
PROVIDER: S-EPMC4745796 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Yang Chih-Jen CJ Liu Yu-Peng YP Dai Hong-Ying HY Shiue Yow-Ling YL Tsai Chia-Jung CJ Huang Ming-Shyan MS Yeh Yao-Tsung YT
Oncotarget 20151001 30
Histone deacetylase 6 (HDAC6) is a unique member of the histone deacetylase family. Although HDAC6 is mainly localized in the cytoplasm, it can regulate the activities of the transcription factors in the nucleus. However, a correlation of intracellular distribution of HDAC6 with tumor progression is lacking. In this study, we found that a low frequency of nuclear HDAC6-positive cells in tumors was associated with distant metastasis and a worse overall survival in 134 patients with non-small cell ...[more]