Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC6693917 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wang Ning N Tan Hor-Yue HY Li Sha S Wang Di D Xu Yu Y Zhang Cheng C Xia Wen W Che Chi-Ming CM Feng Yibin Y
Science advances 20190814 8
Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was suppressed in ATMs of diet-induced obese mice and was correlated with adipose tissue inflammation. Loss of SBP2 initiated metabolic activation of ATMs, inducing intracellular react ...[more]