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Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.

ABSTRACT: Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension.

SUBMITTER: Greer EL

PROVIDER: S-EPMC4746603 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.

Greer Eric Lieberman EL Becker Ben B Latza Christian C Antebi Adam A Shi Yang Y

Cell research 20151222 2

Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic ac ...[more]

PMID: 26691751

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