Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC4827821 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Shen Yanqing Y Ng Li Fang LF Low Natarie Pei Wen NP Hagen Thilo T Gruber Jan J Inoue Takao T
PloS one 20160411 4
Mitochondria play a critical role in aging, however, the underlying mechanism is not well understood. We found that a mutation disrupting the C. elegans homolog of Miro GTPase (miro-1) extends life span. This phenotype requires simultaneous loss of miro-1 from multiple tissues including muscles and neurons, and is dependent on daf-16/FOXO. Notably, the amount of mitochondria in the miro-1 mutant is reduced to approximately 50% of the wild-type. Despite this reduction, oxygen consumption is only ...[more]