Ontology highlight
ABSTRACT:
SUBMITTER: Heiss EH
PROVIDER: S-EPMC4746734 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Heiss Elke H EH Liu Rongxia R Waltenberger Birgit B Khan Shafaat S Schachner Daniel D Kollmann Paul P Zimmermann Kristin K Cabaravdic Muris M Uhrin Pavel P Stuppner Hermann H Breuss Johannes M JM Atanasov Atanas G AG Dirsch Verena M VM
Scientific reports 20160209
The etiology of atherosclerosis and restenosis involves aberrant inflammation and proliferation, rendering compounds with both anti-inflammatory and anti-mitogenic properties as promising candidates for combatting vascular diseases. A recent study identified the iridoid plumericin as a new scaffold inhibitor of the pro-inflammatory NF-κB pathway in endothelial cells. We here examined the impact of plumericin on the proliferation of primary vascular smooth muscle cells (VSMC). Plumericin inhibite ...[more]