Ontology highlight
ABSTRACT:
SUBMITTER: Bu LL
PROVIDER: S-EPMC4747200 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Bu Lin-Lin LL Zhao Zhi-Li ZL Liu Jian-Feng JF Ma Si-Rui SR Huang Cong-Fa CF Liu Bing B Zhang Wen-Feng WF Sun Zhi-Jun ZJ
Oncotarget 20151201 39
Signaling transducer and activator 3 (STAT3) and cancer stem cells (CSCs) have garnered huge attention as a therapeutic focus, based on evidence that they may represent an etiologic root of tumor initiation and radio-chemoresistance. Here, we investigated the high phosphorylation status of STAT3 (p-STAT3) and its correlation with self-renewal markers in head neck squamous cell carcinoma (HNSCC). Over-expression of p-STAT3 was found to have increased in post chemotherapy HNSCC tissue. We showed t ...[more]