Ontology highlight
ABSTRACT:
SUBMITTER: Redlich N
PROVIDER: S-EPMC5849045 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Redlich Nathan N Robinson Anthony M AM Nickel Kwangok P KP Stein Andrew P AP Wheeler Deric L DL Adkins Douglas R DR Uppaluri Ravindra R Kimple Randall J RJ Van Tine Brian A BA Michel Loren S LS
Cell death & disease 20180105 1
ErbB3 has been widely implicated in treatment resistance, but its role as a primary treatment target is less clear. Canonically ErbB3 requires EGFR or ErbB2 for activation, whereas these two established treatment targets are thought to signal independently of ErbB3. In this study, we show that ErbB3 is essential for tumor growth of treatment-naive HNSCC patient-derived xenografts. This ErbB3 dependency occurs via ErbB3-mediated control of EGFR activation and HIF1α stabilization, which require Er ...[more]