Ontology highlight
ABSTRACT:
SUBMITTER: Hao J
PROVIDER: S-EPMC4747207 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Hao Jiaqing J Song Xiao X Wang Jingjing J Guo Chengli C Li Yan Y Li Bing B Zhang Yu Y Yin Yanhui Y
Oncotarget 20151201 39
Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors. Its functions in tumor cells are mostly unknown. Here, we show that MAGE-C2 binds directly to the RING domain protein Rbx1, and participates in Skp1-Cullin1-F box protein (SCF) complex. Furthermore, MAGE-C2 can inhibit the E3 ubiquitin ligase activity of SCF complex. Ablation of endogenous MAGE-C2 decreases the level of cyclin E and accelerates cyclin E turnover by inhibiting ubiqui ...[more]