Ontology highlight
ABSTRACT:
SUBMITTER: Cardote TAF
PROVIDER: S-EPMC5462531 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cardote Teresa A F TAF Gadd Morgan S MS Ciulli Alessio A
Structure (London, England : 1993) 20170601 6
Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system to catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. CRLs are large dynamic complexes and attractive drug targets for the development of small-molecule inhibitors and chemical inducers of protein degradation. The atomic details of whole CRL assembly and interactions that dictate subunit specificity remain elusive. Here we present the crystal structure of a pentameric C ...[more]