Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC4747350 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wu Zheng Z Zhang Zhe Z Ge Xiaoxiao X Lin Ying Y Dai Congqi C Chang Jinjia J Liu Xinyang X Geng Ruixuan R Wang Chenchen C Chen Huan H Sun Menghong M Guo Weijian W Li Jin J
Oncotarget 20151201 38
Despite the promising results from initial studies, there are significant limitations in the application of MET-targeted therapy in gastric cancer. Intrinsic resistance is one of the major obstacles. The aim of this study is to identify the responsible receptor tyrosine kinases (RTKs) that determine the unresponsiveness of MET inhibitor in MET-positive gastric cancer. through an RNA-interference-based functional screen targeting most human RTKs, we identified that activation of the fibroblast gr ...[more]