Ontology highlight
ABSTRACT:
SUBMITTER: Xiao D
PROVIDER: S-EPMC4747359 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Xiao Daibiao D Ren Ping P Su Hexiu H Yue Ming M Xiu Ruijuan R Hu Yufeng Y Liu Hudan H Qing Guoliang G
Oncotarget 20151201 38
Deamidation of glutamine to glutamate by glutaminase 1 (GLS1, also called GLS) and GLS2 is an essential step in both glutaminolysis and glutathione (GSH) biosynthesis. However, mechanisms whereby cancer cells regulate glutamine catabolism remains largely unknown. We report here that N-Myc, an essential Myc family member, promotes conversion of glutamine to glutamate in MYCN-amplified neuroblastoma cells by directly activating GLS2, but not GLS1, transcription. Abrogation of GLS2 function profoun ...[more]