Prevalence of deleterious ATM germline mutations in gastric cancer patients.
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ABSTRACT:
SUBMITTER: Huang DS
PROVIDER: S-EPMC4747381 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Prevalence of deleterious ATM germline mutations in gastric cancer patients.
Huang Dong-Sheng DS Tao Hou-Quan HQ He Xu-Jun XJ Long Ming M Yu Sheng S Xia Ying-Jie YJ Wei Zhang Z Xiong Zikai Z Jones Sian S He Yiping Y Yan Hai H Wang Xiaoyue X
Oncotarget 20151201 38
Besides CDH1, few hereditary gastric cancer predisposition genes have been previously reported. In this study, we discovered two germline ATM mutations (p.Y1203fs and p.N1223S) in a Chinese family with a history of gastric cancer by screening 83 cancer susceptibility genes. Using a published exome sequencing dataset, we found deleterious germline mutations of ATM in 2.7% of 335 gastric cancer patients of different ethnic origins. The frequency of deleterious ATM mutations in gastric cancer patie ...[more]
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