Ontology highlight
ABSTRACT:
SUBMITTER: Bolduc DM
PROVIDER: S-EPMC4747693 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Bolduc David M DM Montagna Daniel R DR Gu Yongli Y Selkoe Dennis J DJ Wolfe Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20151222 5
γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding of most of the substrate's ectodomain by α- or β-secretases. The mechanism by which γ-secretase selectively recognizes and recruits ectodomain-shed substrates for catalysis remains unclear. In contrast to previous reports that substrate is actively recruited for catalysis when its remaining short ectodomain interacts with the nicastrin co ...[more]