Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC4748238 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yang Huaxiao H Schmidt Lucas P LP Wang Zhonghai Z Yang Xiaoqi X Shao Yonghong Y Borg Thomas K TK Markwald Roger R Runyan Raymond R Gao Bruce Z BZ
Scientific reports 20160210
An increase in mechanical load in the heart causes cardiac hypertrophy, either physiologically (heart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regurgitation). Understanding cardiac hypertrophy is critical to comprehending the mechanisms of heart development and treatment of heart disease. However, the major molecular event that occurs during physiological or pathological hypertrophy is the dynamic process of sarcomeric addition, and it has not b ...[more]