Ontology highlight
ABSTRACT:
SUBMITTER: Mu H
PROVIDER: S-EPMC4748833 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Mu Hong H Geacintov Nicholas E NE Zhang Yingkai Y Broyde Suse S
Biochemistry 20150818 34
Mammalian global genomic nucleotide excision repair requires lesion recognition by XPC, whose detailed binding mechanism remains to be elucidated. Here we have delineated the dynamic molecular pathway and energetics of lesion-specific and productive binding by the Rad4/yeast XPC lesion recognition factor, as it forms the open complex [Min, J. H., and Pavletich, N. P. (2007) Nature 449, 570-575; Chen, X., et al. (2015) Nat. Commun. 6, 5849] that is required for excision. We investigated extensive ...[more]