Ontology highlight
ABSTRACT:
SUBMITTER: Tago N
PROVIDER: S-EPMC4749351 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20150930 20
Two RNA fragments linked by means of a 2',5' phosphodiester bridge (2' hydroxyl of one fragment connected to the 5' hydroxyl of the other) constitute a class of nucleic acids known as 2'-5' branched RNAs (bRNAs). In this report we show that bRNA analogues containing 2'-5' phosphoramidate linkages (bN-RNAs) inhibit the lariat debranching enzyme, a 2',5'-phosphodiesterase that has recently been implicated in neurodegenerative diseases associated with aging. bN-RNAs were efficiently generated using ...[more]