FGF21 Regulates Sweet and Alcohol Preference.
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ABSTRACT:
SUBMITTER: Talukdar S
PROVIDER: S-EPMC4749404 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
FGF21 Regulates Sweet and Alcohol Preference.
Talukdar Saswata S Owen Bryn M BM Song Parkyong P Hernandez Genaro G Zhang Yuan Y Zhou Yingjiang Y Scott William T WT Paratala Bhavna B Turner Tod T Smith Andrew A Bernardo Barbara B Müller Christian P CP Tang Hao H Mangelsdorf David J DJ Goodwin Bryan B Kliewer Steven A SA
Cell metabolism 20151224 2
Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-r ...[more]
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