Ontology highlight
ABSTRACT:
SUBMITTER: Ham J
PROVIDER: S-EPMC4749542 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ham Jungoh J Costa Carlotta C Sano Renata R Lochmann Timothy L TL Sennott Erin M EM Patel Neha U NU Dastur Anahita A Gomez-Caraballo Maria M Krytska Kateryna K Hata Aaron N AN Floros Konstantinos V KV Hughes Mark T MT Jakubik Charles T CT Heisey Daniel A R DA Ferrell Justin T JT Bristol Molly L ML March Ryan J RJ Yates Craig C Hicks Mark A MA Nakajima Wataru W Gowda Madhu M Windle Brad E BE Dozmorov Mikhail G MG Garnett Mathew J MJ McDermott Ultan U Harada Hisashi H Taylor Shirley M SM Morgan Iain M IM Benes Cyril H CH Engelman Jeffrey A JA Mossé Yael P YP Faber Anthony C AC
Cancer cell 20160201 2
Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor high-level amplification of MYCN, which correlates with poor disease outcome. Using data from our large drug screen we predicted, and subsequently demonstrated, that MYCN-amplified neuroblastomas are sensitive to the BCL-2 inhibitor ABT-199. This sensitivity occurs in part through low anti-apoptotic BCL-xL expression, high pro-apoptotic NOXA expression, and paradoxical, MYCN-driven upregulation of NOXA. ...[more]