Ontology highlight
ABSTRACT:
SUBMITTER: Balibar CJ
PROVIDER: S-EPMC4750690 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Balibar Carl J CJ Grabowicz Marcin M
Antimicrobial agents and chemotherapy 20151123 2
Gram-negative bacteria provide a particular challenge to antibacterial drug discovery due to their cell envelope structure. Compound entry is impeded by the lipopolysaccharide (LPS) of the outer membrane (OM), and those molecules that overcome this barrier are often expelled by multidrug efflux pumps. Understanding how efflux and permeability affect the ability of a compound to reach its target is paramount to translating in vitro biochemical potency to cellular bioactivity. Herein, a suite of P ...[more]