Ontology highlight
ABSTRACT:
SUBMITTER: Bargiela-Iparraguirre J
PROVIDER: S-EPMC4751465 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Bargiela-Iparraguirre J J Prado-Marchal L L Fernandez-Fuente M M Gutierrez-González A A Moreno-Rubio J J Muñoz-Fernandez M M Sereno M M Sanchez-Prieto R R Perona R R Sanchez-Perez I I
Scientific reports 20160212
Radiation has a limited but relevant role in the adjuvant therapy of gastric cancer (GC) patients. Since Chk1 plays a critical function in cellular response to genotoxic agents, we aimed to analyze the role of Chk1 in GC as a biomarker for radiotherapy resistance. We analyzed Chk1 expression in AGS and MKN45 human GC cell lines by RT-QPCR and WB and in a small cohort of human patient's samples. We demonstrated that Chk1 overexpression specifically increases resistance to radiation in GC cells. A ...[more]