Ontology highlight
ABSTRACT:
SUBMITTER: Eich C
PROVIDER: S-EPMC4751618 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Eich Christina C Manzo Carlo C de Keijzer Sandra S Bakker Gert-Jan GJ Reinieren-Beeren Inge I García-Parajo Maria F MF Cambi Alessandra A
Scientific reports 20160212
Sphingolipids are essential constituents of the plasma membrane (PM) and play an important role in signal transduction by modulating clustering and dynamics of membrane receptors. Changes in lipid composition are therefore likely to influence receptor organisation and function, but how this precisely occurs is difficult to address given the intricacy of the PM lipid-network. Here, we combined biochemical assays and single molecule dynamic approaches to demonstrate that the local lipid environmen ...[more]