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The Neurobiology of Anesthetic Emergence.

ABSTRACT: Achieving a smooth and rapid emergence from general anesthesia is of particular importance for neurosurgical patients and is a clinical goal for neuroanesthesiologists. Recent data suggest that the process of emergence is not simply the mirror image of induction, but rather controlled by distinct neural circuits. In this narrative review, we discuss (1) hysteresis, (2) the concept of neural inertia, (3) the asymmetry between the neurobiology of induction and emergence, and (4) recent attempts at actively inducing emergence.

SUBMITTER: Tarnal V 

PROVIDER: S-EPMC4752918 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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The Neurobiology of Anesthetic Emergence.

Tarnal Vijay V   Vlisides Phillip E PE   Mashour George A GA  

Journal of neurosurgical anesthesiology 20160701 3

Achieving a smooth and rapid emergence from general anesthesia is of particular importance for neurosurgical patients and is a clinical goal for neuroanesthesiologists. Recent data suggest that the process of emergence is not simply the mirror image of induction, but rather controlled by distinct neural circuits. In this narrative review, we discuss (1) hysteresis, (2) the concept of neural inertia, (3) the asymmetry between the neurobiology of induction and emergence, and (4) recent attempts at  ...[more]

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